- PII
- S30345057S2686738925040156-1
- DOI
- 10.7868/S3034505725040156
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 523 / Issue number 1
- Pages
- 469-473
- Abstract
- Despite significant progress in oncotherapy, oncological diseases continue to pose a serious problem for public health. The limited penetration of nanoscale therapeutic drugs into solid tumors, due to the presence of tight intercellular junctions, does not allow achieving therapeutically effective drug concentrations in distal tumor cells, which leads to the appearance of drug resistance. In this work, to increase the accumulation of HER2-specific small gold nanoparticles (DARPin-AuNPs) in solid tumors, the use of these particles in combination with the protein-opener of desmoglein junctions JO-4 is proposed. A quantitative assessment of gold biodistribution in mice showed that co-administration of DARPin-AuNP/JO-4 in vivo increased particle accumulation in tumors by approximately 2.5-fold compared to administration of DARPin-AuNP alone.
- Keywords
- адресная терапия золотые наночастицы DARPin HER2
- Date of publication
- 15.06.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 46
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